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KMID : 0355620200460040282
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2020 Volume.46 No. 4 p.282 ~ p.287
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Undifferentiated pleomorphic sarcoma of the mandible
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Benites Bernar Monteiro
Miranda-Silva Wanessa
Fonseca Felipe Paiva
de Oliveira Claudia Regina Gomes Cardim Mendes
Fregnani Eduardo Rodrigues
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Abstract
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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindlecell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.
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KEYWORD
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Soft tissue sarcoma, Pleomorphic sarcoma, Malignant fibrous histiocytoma, Oral cavity, Mandible
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